Core Investigators

Perelman School of Medicine at The University of Pennsylvania Scientific & Data Coordinating Center

Harold I. Feldman, MD, MSCE

Dr. Harold I. Feldman is a Professor of Medicine and Epidemiology at the Perelman School of Medicine at The University of Pennsylvania; Chair, Department of Biostatistics and Epidemiology; and Director, Center for Clinical Epidemiology and Biostatistics (CCEB). His major research interests address the epidemiology of kidney diseases with a particular focus on the management of kidney disease at all stages and the prevention of progression from early stages of kidney dysfunction to end-stage renal disease. He leads CCEB-based researchers and several national research groups studying various manifestations and treatment of kidney disease. These research programs are investigating the causes of failure of vascular accesses used for hemodialysis, anemia and metabolic disorders of kidney disease, the determinants of long-term survival of kidney transplants, the epidemiology of drug-related kidney disease, the relationships between ethnicity and kidney diseases, the inter-relationship between chronic kidney disease and cardiovascular disease, and pediatric kidney diseases. Dr. Feldman is the national study chair of the NIH/NIDDK Hemodialysis Fistula Maturation Cohort Study (HFM) and the NIH/NIDDK Chronic Renal Insufficiency Cohort Study (CRIC). He is also the principal investigator of the Scientific and Data Coordinating Center of the CRIC Study.

J. Richard Landis, PhD

Dr. J. Richard Landis is Professor of Biostatistics at the Perelman School of Medicine at The University of Pennsylvania, and holds a secondary appointment as Professor of Statistics in the Wharton School. Dr. Landis serves as Director of the Biostatistics Unit within the Center for Clinical Epidemiology and Biostatistics (CCEB), and Co-Director of the Clinical Research Computing Unit (CRCU), a designated core research facility providing clinical research informatics collaboration and services for a growing number of clinical and translational research investigators at Penn. He is PI of the Data Coordinating Core for the NIH/NIDDK Multidisciplinary Approach to Pelvic Pain (MAPP) Research Network, and serves as Co-PI for the Scientific and Data Coordinating Center for the CRIC Research Network. Dr. Landis also serves as Co-Director for the CTSA-funded Center for Biomedical Informatics in Translation, promoting clinical research informatics best practices, and as the Director of the Biomedical Data Coordination Core (BDCC), a new core within the Abramson Cancer Center NCI Core grant. Dr. Landis has been actively involved in collaborative biomedical research, and the development and evaluation of methods for the analysis of categorical data. His publications are in the areas of statistical methods for repeated measurement and longitudinal categorical data, epidemiological studies, complex sample surveys and applications to cardiovascular, ophthalmology, respiratory, psychiatric, renal and urological research.

University of Pennsylvania-Renal Research

Raymond R. Townsend, MD

Dr. Raymond R. Townsend is a Professor of Medicine in the Renal Division at the Perelman School of Medicine at The University of Pennsylvania; the Director of the Penn Hypertension Program, Hospital of the University of Pennsylvania; and an Associate Director of the Clinical & Translational Research Center component of the University of Pennsylvania's CTSA award. His principal research interests focus on the role of hypertension and in particular mechanisms of kidney damage that are related to pulse wave travel and pulse wave reflection in the circulation; and in the role of metabolism, specifically the linkages between insulin resistance and kidney disease progression in people with chronic kidney disease. These two areas (arterial stiffness and metabolism) link the role of hemodynamics (as reflected in both blood pressure and vascular stiffness) to a variety of outcomes in CKD including heart failure, cognitive function changes, retinopathy, CKD progression and vascular calcification. He is the Principal Investigator of the Pulse Wave Velocity in CKD ancillary project in the Chronic Renal Insufficiency Cohort Study (CRIC), and also the Principal Investigator of the Penn Clinical Center in the CRIC Study.

Johns Hopkins University ProHealth

Lawrence Appel, MD, MPH

Dr. Lawrence Appel is Director of the Welch Center for Prevention, Epidemiology and Clinical Research, a joint program of the School of Medicine and the Bloomberg School of Public Health at Johns Hopkins University. Dr. Appel is a Professor of Medicine with adjunct appointments in Epidemiology and International Health. The focus of Dr. Appel's investigative career is the conduct of clinical, epidemiologic and translational research pertaining to the prevention of hypertension, cardiovascular disease, and kidney disease.

Currently, Dr. Appel has three large, complementary research programs:

  • large-scale trials of dietary changes to prevent disease
  • behavioral intervention trials that test novel strategies to accomplish lifestyle modification, often focused on obesity
  • trials and observational studies to understand risk factors for chronic kidney disease progression and its complications

A particularly notable feature of this research is the focus on conditions and diseases that disproportionately afflict minorities and on interventions that have the potential to substantially reduce racial disparities.

Dr. Appel has been actively involved in health care policy. He was a member of the 2005 and 2010 U.S. Dietary Guidelines Scientific Advisory Committees. For the American Heart Association, he has been a member of its Nutrition Committee for over 10 years and a past chair. He has also served on several Institute of Medicine Committees and chaired the committee that set dietary reference intakes for sodium, potassium and water. He has served on numerous advisory committees for the National Institutes of Health.

University of Maryland

Jeffrey Fink, MD, MS

Dr. Jeffrey C. Fink is a Professor in the Department of Medicine with a secondary appointment in the Department of Epidemiology and Public Health at the University of Maryland School of Medicine. He serves as the Division Chief of General Internal Medicine at that institution. He founded and coordinates the Early Renal Insufficiency (ERI) program offering patients several opportunities for participation in clinical research at 2 clinical sites (one each at the Baltimore VA and University of Maryland Medical System). Dr. Fink's research background is as both a clinical investigator and a clinical epidemiologist with interest in all aspects of chronic kidney disease. His activities as a clinical investigator include serving as a site investigator for the NIH/NIDDK Chronic Renal Insufficiency Cohort Study (CRIC) and Principal Investigator of the Safe Kidney Care and Safe Kidney eCare studies. As a clinical epidemiologist he has conducted several secondary analyses of existing databases including the USRDS and national VA data and he is currently PI of the NIDDK-funded CRIC-Safety study, which is an ancillary to the core CRIC examining the influence of safety events on adverse outcomes among CRIC participants.

University Hospitals Case Medical Center

Mahboob Rahman, MD, MS

Dr. Mahboob Rahman is an Associate Professor of Medicine at Case Western Reserve University, and a staff nephrologist at University Hospitals Case Medical Center and the Louis Stokes Cleveland VA Medical Center. His areas of research interest include hypertension, chronic kidney disease, and cardiovascular risk in patients with chronic kidney disease.

MetroHealth Medical Center

Edward J. Horwitz, MD

 

 

The Cleveland Clinic Foundation

Jonathan J. Taliercio, DO

Dr. Taliercio received his medical degree from New York College of Osteopathic Medicine in Long Island, NY. He completed his Internal Medicine residency and Nephrology and Hypertension fellowship at The Cleveland Clinic Glickman Urological and Kidney Institute, where he has been on staff since 2010. He is Associate Professor for the Cleveland Clinic Lerner College of Medicine. Dr. Taliercio is the Associate Program Director for the Nephrology Fellowship Program and the Specialty Education Coordinator for the Internal Medicine Residency Program. His clinical interests include chronic kidney disease, resistant hypertension, and glomerulonephritis.

University of Michigan Hospital and Health Systems

Panduranga Rao, MD

 

 

Wayne State University School of Medicine

James H. Sondheimer, MD

James H. Sondheimer, MD is Associate Professor of Medicine at Wayne State University School of Medicine in Detroit, Michigan, where he is Interim Division Chief of Nephrology. Dr. Sondheimer is a Fellow of the American College of Physicians and the American Society of Nephrology and is certified in Clinical Hypertension (ASH). He is a graduate of Albert Einstein College of Medicine, and completed his Medicine and Nephrology training at North Shore University Hospital and Memorial Hospital in New York. His research interests revolve around ESRD, CKD, and measurement of renal function, as well as trace element metabolism. He has been associated with CRIC at Wayne State since 2004.

University of Illinois at Chicago

James P. Lash, MD

Dr. James Lash is Professor of Medicine in the Division of Nephrology at the University of Illinois at Chicago. Dr. Lash's research focuses on the epidemiology of chronic kidney disease and interventional trials in the treatment of kidney disease, particularly in racial and ethnic minority populations in the United States. In addition to being the Principal Investigator of the University of Illinois CRIC Clinical Center, he is the Principal Investigator for the Hispanic CRIC Study and the Fogarty-sponsored Mexican Chronic Renal Insufficiency Cohort Study based at the Instituto Nacional de Cardiología Ignacio Chávez in Mexico City. Dr. Lash is also the recipient of a Midcareer Investigator Award in Patient-Oriented Research (K24) which is focused on providing mentorship and training for new physician-scientists in the area of health disparities in chronic kidney disease. Dr. Lash has had considerable experience in recruitment and retention for clinical trials, including the Systolic Blood Pressure Intervention Trial (SPRINT), and African American Study of Kidney and Hypertension (AASK) Cohort Study, and the Angiotensin II Receptor Antagonist Losartan (RENAAL) Study.

Tulane Office of Health Research

Jiang He, MD, PhD

Dr. Jiang He is the Joseph S. Copes, M.D. Chair and Professor of the Department of Epidemiology at the Tulane University School of Public Health and Tropical Medicine. He is also Professor of Clinical Medicine and Human Genetics at the Tulane University School of Medicine. Dr. He is a nationally and internationally well-known expert in the prevention and epidemiology of cardiovascular and kidney diseases. He has conducted novel studies in hypertension, obesity, stroke, cardiovascular disease, and chronic kidney disease funded by the National Heart, Lung, and Blood Institute; the National Institute of Diabetes and Digestive and Kidney Diseases; and American Heart Association. Dr. He has authored or co-authored more than 270 scientific articles which were published in first class biomedical journals, including the New England Journal of Medicine, the Journal of American Medical Association, and the Lancet. He has received many awards from local, national, and international academic institutions and professional societies.

Kaiser Permanente of Northern California

Alan S. Go, MD

Dr. Alan S. Go is Chief of the Cardiovascular and Metabolic Condition Section and Director of the Comprehensive Clinical Research Unit at the Kaiser Permanente Northern California Division of Research. He is also Regional Medical Director of Clinical Trials for Kaiser Permanente Northern California and Associate Professor in the Departments of Epidemiology, Biostatistics, and Medicine at the University of California, San Francisco. Dr. Go is Principal Investigator of the Kaiser Permanente Northern California/UCSF CRIC Clinical Research Center. Dr. Go's research interests include characterizing the epidemiology of acute, chronic and end-stage renal disease; optimizing treatment and outcomes of cardiovascular and renal disease; prevention and treatment of acute and chronic kidney disease; epidemiology, management of atrial fibrillation, heart failure and ischemic heart disease; and genetic and other biomarker predictors of cardiovascular complications.

University of California, San Francisco

Chi-yuan Hsu, MD, MSc

Dr. Chi-yuan Hsu graduated from Yale University in 1989 with simultaneous B.S. and M.S. degrees. He obtained his M.D. from Harvard Medical School and completed his internal medicine residency at Boston's Beth Israel Hospital. Dr. Hsu went on to a nephrology fellowship at the Massachusetts General Hospital and graduated from the Harvard School of Public Health with a M.Sc. degree in epidemiology. Dr. Hsu has been at the University of California San Francisco (UCSF) Division of Nephrology since 1999 where he is now Professor and Division Chief. His research has been supported by the National Institutes of Health and focuses on the epidemiology of acute, chronic and end-stage renal disease. He is a member of the American Society of Clinical Investigation.

National Institute of Diabetes, Digestive, & Kidney Diseases, NIH

Andrew S Narva, MD

Dr. Andrew Narva is the director of the National Kidney Disease Education Program (NKDEP) at the National Institutes of Health. Prior to joining the NKDEP in 2006, he served as chief clinical consultant for nephrology and director of the Kidney Disease Program for the Indian Health Service (IHS). He has served as a member of the Medical Review Board of ESRD Network 15 and as chair of the Minority Outreach Committee of the National Kidney Foundation (NKF). He served on the NKF KDOQI Work Group on Diabetes in Chronic Diabetes, as a member of the JNC 8 Expert Panel, and as a member of Working Group on CKD, International Federation of Clinical Chemistry and Laboratory Medicine. During 2002 Dr. Narva was recognized by the US Public Health Service as the Clinical Physician of the Year. Dr. Narva continues to serve as the Chief Clinical Consultant for Nephrology for IHS and continues to provide care for patients at Zuni Pueblo through a telemedicine clinic.

John W. Kusek, PhD

Dr. John W. Kusek is Senior Scientific Advisor in the Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health. He has been involved with a number of large-scale clinical trials in nephrology including the Modification of Diet in Renal Disease (MDRD) Study, the African American Study of Kidney Disease and Hypertension (AASK) and the Hemodialysis (HEMO) Study. He is currently Project Scientist for the Chronic Renal Insufficiency Cohort (CRIC) Study and an observational study of fistula maturation, the Hemodialysis Fistula Maturation Cohort Study. He has also been involved with a number of clinical trial and epidemiologic studies of urologic diseases (non-malignant). He has authored or co-authored over 200 papers. He serves on the editorial board of CJASN.

Tracy Rankin, PhD, MPH

Dr. Tracy Rankin is the program director for career development and training in the Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK). She manages a portfolio of career development and fellowship awards encompassing all aspects of renal and benign urologic disease. Additionally, she manages a research portfolio focused on urologic complications of diabetes and molecular endocrinology of the lower genitourinary tract. She also serves as the program official for the O’Brien Urology Centers program. Prior to coming to the NIDDK, Dr. Rankin served as the program official for the Reproductive Medicine Network and the Specialized Cooperative Centers Program in Reproduction and Infertility Research (now called the National Centers for Translational Research in Reproduction and Infertility) at the Eunice Kennedy Shriver National Institute of Child Health and Human Development. 

 

CRIC Scientific Discoveries

FGF23 elevation has been linked to greater risks of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD), but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with prevalent and incident LVH among CRIC Study participants.
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CRIC Collaborations

The CRIC Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies approved by the CRIC Cohort utilizing both data collected about CRIC study participants as well as their biological samples.
Learn more about collaborating with CRIC >>
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