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Research Collaborations

The Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies supported by the CRIC Cohort utilizing both CRIC study participants and biological samples obtained from CRIC study participants. Through the CRIC data sharing policy, investigators have an opportunity to tap into the rich CRIC data to pursue their own research goals.

In addition to the CRIC Clinical Centers listed on the Participating Institutions page, collaborative research partnerships are currently conducted at a number of institutions across the country including, but not limited to, University of Utah, University of Miami, University of North Carolina, George Washington University, University of Alabama, as well as at international sites in China, Japan, Peru, and Germany. The currently ongoing CRIC ancillary studies are listed below by year of funding.

The CRIC Ancillary Study Policy provides information regarding the requirements and procedures for approval of an ancillary study. See section XII for instructions on the submission process. Section XIV details the procedural steps involved in the review. Also see Template for Ancillary Study Submission.

2017

  • Vitamin K status, CVD and arterial stiffness in chronic kidney disease: The Chronic Renal Insufficiency Cohort [R01]
    Kyla Shea | Tufts University
    keywords: Vitamin K, matrix gla protein, kidney function, CVD, arterial stiffness

  • MicroRNAs in progressive renal disease – a pilot study in CRIC (MIRROR-TRIC) [CKD Biomarkers Pilot and Feasibility Program
    Christos Argyropoulos | University of New Mexico
    keywords: microRNAs, Chronic Kidney Disease, Proteinuria, RNA-seq, biomarkers, measures of renal function

2016

  • Weight trajectory in chronic kidney disease and risk of adverse outcomes [National Kidney Foundation]
    Elaine Ku | University of California, San Francisco
    keywords: weight loss, BMI, CKD, ESRD

  • Identifying Modifiable Biomarkers/Mediators for Cardiovascular Disease in Chronic Kidney Disease
    Peter Ganz | University of California, San Francisco
    keywords: cardiovascular risk prediction model; chronic kidney disease; proteomics

  • The Gut Microbiome and the metabolome in CKD [R01]
    Amanda Hyre Anderson, PhD, MPH | University of Pennsylvania
    keywords: gut microbiota, metabolomics, metabolic profiling, CKD

  • Assessing the accuracy of information in the CMS Medical Evidence Report (form CMS-2728) [K24]
    Chi-yuan Hsu | University of California, San Francisco
    keywords: incident ESRD, co-morbidity, information bias

  • Novel Diagnostics and Therapeutic Targets for Calcification in CKD [R01]
    Tamara Isakova | Northwestern University
    keywords: vascular calcification; calcification propensity; calciprotein particles

  • Assessment of nicotine exposure from toenail clippings of CRIC participants [Pilot]
    Edgar Jaimes | MSKCC
    keywords: nicotine, smoking, chronic kidney disease (CKD)

  • Tubular Secretion and Chronic Kidney Disease Complications [R01]
    Bryan Kestenbaum | University of Washington
    keywords: tubular secretion, biomarkers, kidney, hippurate

  • Metabolomics for Identifying Biomarkers of Dietary Intake & Kidney Disease Progression [K01]
    Casey Rebholz | Johns Hopkins University
    keywords: diet; metabolomics; kidney disease progression

2015

  • Prognostic biomarkers in chronic kidney disease
    Farsad Afshinnia | University of Michigan
    keywords: chronic kidney disease, progression, end stage renal disease, biomarker, metabolomics, Mass spectrometry

  • Heart failure and arrhythmias in CKD
    Nisha Bansal, MD, MAS | University of California, San Francisco
    keywords: heart failure, prediction, cardiac arrhythmias, biomarkers

  • Pilot Study on Proteomics of Kidney Disease Progression in the CRIC Study
    Rajat Deo | University of Pennsylvania
    keywords: proteomics, progressive kidney disease, SOMAscan

  • Measures of fibrosis and clinical outcomes in chronic kidney disease
    Amanda Hyre Anderson, PhD, MPH | University of Pennsylvania
    keywords: fibrosis, CKD progression, cardiovascular disease, galectin-3, CTGF or CCN2, collagen type III, MMP-2

  • Whole-exome sequencing study of diabetic nephropathy
    Tanika Kelly | Tulane University
    keywords: diabetic nephropathy; next-generation sequencing; whole-exome sequencing; rare variants; low frequency variants

  • Longitudinal Changes in Metabolomic Biomarkers and CKD Progression
    Eugene Rhee | Massachusetts General Hospital/Broad Institute
    keywords: metabolomics, CKD, CKD progression

  • Epigenetic dysregulation in diabetic kidney disease
    Katalin Susztak | University of Pennsylvania
    keywords: cytosine methylation, epigenetics

  • Oxalate in CKD Pathogenesis and Progression
    Sushrut Waikar | Brigham and Women’s Hospital
    keywords: oxalate; chronic kidney disease; cardiovascular disease; decline in GFR

2014

  • Is there a digital divide in chronic kidney disease?
    Clarissa Diamantidis | Duke University
    keywords: CKD, health information technology, e-literacy, patient safety

  • Performance of Vitamin D-Binding Protein (DBP) ELISA by Genotype: Validation using Mass Spectrometry
    Mary Leonard, Michelle Denburg | Stanford University/Children’s Hospital of Philadelphia
    keywords: Vitamin D, vitamin D-binding protein, genotype

  • Visceral adiposity and fitness among CRIC participants (phase 3)
    Sankar Navaneethan | Cleveland Clinic
    keywords: Obesity, fitness, and kidney disease

  • Novel metabolites associated with renal outcomes
    Tammy Sirich | Stanford University
    keywords: mass spectrometry, metabolomic, CKD

  • Trimethylamine N-oxide and Disease Progression in the CRIC Study
    Wilson Tang, M.D. | Cleveland Clinic
    keywords: Intestinal microflora, trimethylamine N-oxide

  • Plasma KIM-1 and Chronic Kidney Disease
    Sushrut Waikar | Brigham and Women’s Hospital
    keywords: Tubular injury; biomarkers of progression

2013

  • Pathophysiological Role of Prorenin
    Alfred Cheung, M.D. | University of Utah
    keywords: Prorenin, chronic kidney disease, retinopathy, cardiovascular disease, diabetes

  • Vitamin D catabolism in chronic kidney disease
    Ian de Boer | University of Washington
    keywords: Vitamin D, mineral metabolism, CKD

  • Serum Bicarbonate and Cardiovascular Risk in Patients with Chronic Kidney Disease
    Mirela Dobre, M.D. | Case Western Reserve University
    keywords: metabolic acidosis, metabolic alkalosis, cardiovascular disease, mortality

  • Enhancing appreciation of the clinical significance of acute kidney injury
    Raymond Hsu | University of California, San Francisco
    keywords: Acute kidney injury (AKI), chronic kidney disease (CKD)

  • Estimating GFR from a Panel of Endogenous Filtration Markers (Panel eGFR)
    Lesley Inker | Tufts Medical Center
    keywords: GFR, beta trace protein, beta 2 microglobulin, cystatin C, creatinine

  • Role of Sclerostin in Disordered Mineral Metabolism in CKD
    Tamara Isakova, MD, MMSc | Northwestern University
    keywords: CKD, sclerostin, FGF23, PTH, phosphate

  • Validation of the Kidney Knowledge Survey (KiKS) in Hispanics with Chronic Kidney Disease
    Claudia Lora | University of Illinois at Chicago
    keywords: Hispanics, Chronic Kidney Disease Knowledge, Spanish language

  • Gender Disparities and Endogenous Estrogen in Chronic Kidney Disease Outcomes
    Ana Ricardo, MD, MPH, MS | University of Illinois, Chicago
    keywords: Sex hormones, gender disparities

  • Mediators & Prognostic Value of Muscle Mass & Function in Chronic Kidney Disease
    Perry Wilson, M.D. | Yale University
    keywords: Sarcopenia, creatinine generation rate, chronic kidney disease, myostatin, caspase-3, activin A, inflammation, tnf-alpha, tgf-beta, frailty

  • FGF-23 and Clinical Outcomes in ADPKD Patients
    Myles S. Wolf, MD, MMSc | Northwestern University
    keywords: FGF23, CKD, ADPKD, phosphate

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2012

  • Metabolomic Studies in Chronic Kidney Disease
    Harold I. Feldman, MD, MSCE | University of Pennsylvania
    keywords: metabolomics

  • Health Disparities in Chronic Kidney Disease
    James Lash, MD | University of Illinois, Chicago
    keywords: socioeconomic status, health literacy, health disparities

  • Mexico Chronic Renal Insufficiency Cohort (MCRIC)
    James Lash, M.D. | University of Illinois, Chicago
    keywords: Chronic kidney disease progression, Hispanics, Mexico

  • Acidosis, Net Acid Excretion and Morbidity in CKD
    Julia Scialla, MD, MHS | Duke University
    keywords: metabolic acidosis, nutrition, bone and mineral metabolism, urinary electrolytes, progression, cardiovascular disease, mortality

  • Genetics of Race and Disordered Mineral Metabolism in CKD
    Myles S. Wolf, MD, MMSc | Northwestern University
    keywords: phosphate, FGF23, klotho, CKD, CVD, genetics, ancestry, racial disparities

2011

  • Modifiable and Novel Risk Factors for and Consequences of Acute Kidney Injury in the Setting of Chronic Kidney Disease: a CRIC Ancillary Study
    Amanda Hyre Anderson, PhD, MPH | University of Pennsylvania
    keywords: acute kidney injury, progression, mortality

  • Do patient safety events account for adverse outcomes in CKD?
    Jeffrey Fink, MD | University of Maryland
    keywords: safety incidents, outcomes, metabolic disturbance

  • Abrupt Transition to ESRD from CKD
    Chi-yuan Hsu, MD, MSc | University of California, San Francisco
    keywords: ESRD, transition

  • CKD Blood Biomarker Discovery (sub-protocol of the CKD Biomarkers Consortium)
    Lesley Inker, MD, MS | Tufts University
    keywords: biomarkers, progression, proteomics

  • Hispanic Chronic Renal Insufficiency Cohort (Renewal)
    James Lash, MD | University of Illinois, Chicago
    keywords: Hispanic, cardiovascular disease, progression

  • Novel Paradigm to Understand Diabetic Complications
    Kumar Sharma, MD | University of California, San Diego
    keywords: mitochondria, urine metabolomics, nephropathy, retinopathy

  • Cognitive Decline in Chronic Renal Insufficiency (Renewal)
    Manjula Tamura, MD, MPH and Kristine Yaffe, MD | Stanford University
    keywords: cognitive function, gfr, decline, oxidative stress markers

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2010

  • Hypertension in Advanced Chronic Kidney Disease
    Nisha Bansal, MD, MAS | University of California, San Francisco
    keywords: hypertension, progression, ESRD, blood pressure, cardiovascular disease

  • The Effect of Sickle Cell Trait upon Progression of Chronic Kidney Disease
    Vimal Derebail, MD, MPH | University of North Carolina
    keywords: risk factors, sickle cell trait, hemoglobinopathy

  • Elevated Nighttime BP – Clinical and Demographic Features, Correlates, and Changes Over Time
    Paul E. Drawz, MD, MHS | Case Western Reserve University
    keywords: hypertension, blood pressure, nighttime ABP

  • Joint Analysis of Longitudinal Outcomes and Clinical Events in Chronic Kidney Disease Cohorts
    Tom Greene, PhD | University of Utah
    keywords: longitudinal analysis, statistical methods, multi-state models, causal models

  • Health Literacy, Acculturation and Social Support in Hispanics with Chronic Kidney Disease
    Claudia Lora, MD | University of Illinois, Chicago
    keywords: HCRIC, health literacy, Hispanic, acculturation, risk factors, cardiovascular disease

  • Validation of the Beck Depression Inventory in Hispanics with Chronic Kidney Disease
    Ana C. Ricardo, MD, MPH, MS | University of Illinois, Chicago
    keywords: Beck depression inventory, Hispanic, depression

  • Carbamylated LDL and Cardiovascular Events
    Sudhir V. Shah, MD | University of Arkansas
    keywords: carbamylated LDL, cardiovascular disease, risk factors, atherosclerosis

  • Pulse Wave Velocity (Renewal)
    Raymond Townsend, MD | University of Pennsylvania
    keywords: pulse wave velocity, hemodynamics, blood pressure

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2009

  • The Renin-Angiotensin-Aldosterone System and Cardiac Arrhythmias
    Rajat Deo, MD | University of Pennsylvania
    keywords: atrial fibrillation, renin, aldosterone, angiotensin, cardiovascular disease

  • CKD, Metabolic Syndrome and Cardiovascular Disease
    Harold I. Feldman, MD, MSCE | University of Pennsylvania
    keywords: metabolic syndrome, insulin resistance, cardiovascular disease, progression

  • GWAS in CKD: The CRIC Study
    Harold I. Feldman, MD, MSCE | University of Pennsylvania
    keywords: GWAS, genetics, GFR, progression

  • Chronic Kidney Disease Biomarker Validation
    Chi-yuan Hsu, MD, MSc and Kathleen D. Liu, MD, PhD, MAS | University of California, San Francisco
    keywords: biomarkers, kidney injury

  • The Role of Neuregulin in Human Cardiac Remodeling and Heart Failure
    Bonnie Ky, MD, MSCE | University of Pennsylvania
    keywords: NRG-1, cardiac remodeling

2008

  • Using 2-D Gel to Identify Patterns of Urine Protein Excretion that Predict Loss of GFR
    Chi-yuan Hsu, MD, MSc | University of California, San Francisco
    keywords: two-dimension differential gel electrophoresis, GFR, proteinuria

  • Molecular Predictors of Progressive Renal Failure in the Chronic Renal Insufficiency Cohort
    Matthias Kretzler, MD | University of Michigan
    keywords: progression, molecular predictors, biomarkers

  • Clinical Outcomes of Pre-ESRD CKD Patients with Hepatitis C Infection
    Akinlolu O. Ojo, MD, PhD, MPH | University of Michigan
    keywords: HCV, pre-ESRD

  • Genetic of Lipoprotein Metabolism and CVD in CKD
    Daniel J. Rader, MD | University of Pennsylvania
    keywords: lipoproteins, metabolism, genetics

  • Role of FGF-23 in Mineral Metabolism and CVD in Pre-dialysis CKD
    Myles S. Wolf, MD, MMSc | University of Miami
    keywords: FGF-23, phosphate therapy, hyperphosphatemia, left ventricular mass

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2007

  • Genomics of myocardial transcription factors in cardiac remodeling
    Thomas P. Cappola, MD, ScM | University of Pennsylvania
    keywords: genetics, cardiac remodeling, transcription factors

  • Pulse Wave Velocity and Chronic Kidney Disease
    Stephanie DeLoach, MD | Thomas Jefferson University
    keywords: pulse wave velocity, cardiovascular disease

  • Corin Allelle and Heart Disease
    Daniel L. Dries, MD | Yale University
    keywords: genetics, cardiovascular disease, natriuretic peptide system, cardiac hypertrophy, corin

  • CRIC Plus – Race Group Analysis
    Vanessa Grubbs, MD, MPH | University of California, San Francisco
    keywords: racial disparities, progression, CRIC-plus, ESRD

  • Health Literacy and Acculturation in Hispanic Patients with Chronic Kidney Disease
    Claudia Lora, MD | University of Illinois, Chicago
    keywords: HCRIC, health literacy, Hispanic, acculturation, risk factor, cardiovascular disease

  • Carotid Intima-Media Thickness in Chronic Kidney Disease (Renewal)
    Sylvia Rosas, MD, MSCE | University of Pennsylvania
    keywords: carotid intima-media thickness, carotid plaque, progression, cardiac outcomes

  • KDQOL and the Spanish-Speaking CKD Population
    Julio Vijil, Jr., MD | University of Illinois, Chicago
    keywords: KDQOL , hispanic, HCRIC

2006

  • Sodium and Cardiovascular Disease in Patients with CKD
    Jiang He, MD, PhD | Tulane University
    keywords: Sodium, electrolyte excretion, potassium, cardiovascular disease, cardiac outcomes

  • Study of Advanced Chronic Renal Insufficiency
    Chi-yuan Hsu, MD, MSc | University of California, San Francisco
    keywords: progression, transition to ESRD, GFR

  • Vitamin D Deficiency, Physical Performance and Cardiovascular Disease
    Mary Leonard, MD, MSCE | Children’s Hospital of Philadelphia
    keywords: vitamin D, calcidiol, frailty, PTH

  • Cytokine Gene Polymorphism in the CRIC Cohort
    Dominic Raj, MD | George Washington University
    keywords: cytokine, polymorphism, inflammation

  • Genetics of Atherosclerosis in Renal Disease
    Muredach P. Reilly, MBBCH, MSCE | University of Pennsylvania
    keywords: genetics, atherosclerosis, metabolic syndrome, inflammation

  • KDQOL and the Spanish-Speaking CKD Population
    Julio Vijil, Jr., MD | University of Illinois, Chicago
    keywords: KDQOL, hispanic, HCRIC

2005

  • Diabetic and Hypertensive Retinopathy and CRI
    Juan E. Grunwald, MD | University of Pennsylvania
    keywords: retinopathy, hypertension, diabetes, ophthalmology

  • Hispanic Chronic Renal Insufficiency Cohort
    James Lash, MD | University of Illinois, Chicago
    keywords: hispanic, cardiovascular disease, progression

  • Pulse Wave Velocity and Chronic Kidney Disease
    Raymond Townsend, MD | University of Pennsylvania
    keywords: pulse wave velocity, hypertension, cardiovascular disease

  • Sleep Disturbances as a Non-traditional Risk Factor in CKD
    Eve Van Cauter, PhD | University of Chicago
    keywords: sleep, risk factor, c-reactive protein

  • Cognitive Function in Chronic Renal Insufficiency
    Kristine Yaffe, MD | University of California, San Francisco
    keywords: cognitive function, gfr, depression

2004

  • Development and Validation of GFR Estimating Equations
    Andrew Levey, MD | Tufts University
    keywords: estimated glomerular filtration rate, meta analysis, equation

  • Carotid Intima-Media Thickness in Chronic Kidney Disease
    Sylvia Rosas, MD, MSCE | University of Pennsylvania
    keywords: carotid intima-media thickness, carotid plaque, progression, cardiac outcomes

  • Hispanic Recruitment in CRIC
    Julio Vijil, Jr., MD | University of Illinois, Chicago
    keywords: recruitment, Hispanic

2003 - 2002

  • A Structural Approach to Renal Bone Disease in CRIC
    Mary Leonard, MD, MSCE | Children’s Hospital of Philadelphia
    keywords: renal bone disease, renal osteodystrophy, bone mineral density

  • Hypertension and Hypercholesterolemia Control in Patients with CKD
    Paul Muntner, PhD | University of Alabama at Birmingham
    keywords: hypertension, hypercholesterolemia, cardiovascular disease, hemodynamics, nutrition

  • CRIC Heart Failure Detection Cohort and the CRIC Heart Failure Progression Cohort
    Michael Shlipak, | University of California, San Francisco
    keywords:

  • Nutrition Assessment in Chronic Renal Insufficiency Cohort (CRIC) Study Population
    Cheryl Anderson, PhD, MPH | The Johns Hopkins University
    keywords: nutrition, cerebrovascular disease, protein-energy malnutrition, metabolism

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CRIC Scientific Discoveries

FGF23 elevation has been linked to greater risks of left ventricular hypertrophy (LVH) and mortality in patients with chronic kidney disease (CKD), but whether these risks represent causal effects of FGF23 is unknown. Here, we report that elevated FGF23 levels are independently associated with prevalent and incident LVH among CRIC Study participants.
Learn more >>

CRIC Collaborations

The CRIC Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies approved by the CRIC Cohort utilizing both data collected about CRIC study participants as well as their biological samples.
Learn more about collaborating with CRIC >>
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